Endocrine Abstracts

Introduction: Type 2 diabetes represents an important health problem and is designated by a progressive course, and the subsequent long-term insulin therapy to achieve optimal glucose control. It is important to stress that a substantial number of patients do not achieve optimal glucose control despite the usage of two doses of premixed insulin. Detemir insulin, along with a low pharmacodynamic coefficient of variability, exhibits anorexigenic features, through its effects on ...

Introduction: Patients with diabetes (DM) are at increased risk for cardiovacular disease (CVD). Possible effects of insulin therapy on development of atherosclerosis and CVD were studied.Patients and methods: Relevant metabolic parameters were determined in 348 patients assigned into groups with DM2 on oral hypoglycemic drugs (DM2-OH) and insulin (DM2-INS), and with DM1.Results: A significant among-group difference was found in ad...

Introduction: Growing evidence suggests that nutrients and hormonal signals converge and directly act on brain centers, leading to changes in energy metabolism and stable body weight over time. Catechol O-methyltransferase (COMT) is one of the major enzymes involved in catecholamine and estrogen degradation. There is a well-established association between the COMT Val108/158Met polymorphism and abdominal obesity, blood pressure increase and T2DM. Basal insulin detemir besides ...

: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It’s a heterogeneous functional disorder of unclear etiology. The features of PCOS are disorders of ovulation, androgen excess, polycystic ovaries; it’s associated with presence of associated risk factors for cardiovascular disease (obesity, glucose intolerance, dyslipidemia). The diagnosis of PCOS is made using the Rotterdam 2003 criteria. 23yo female patie...